Keep an eye on Intently (1)lumefantrine will minimize the extent or effect of exemestane by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. For people acquiring exemestane that has a potent CYP3A4 inducer the encouraged dose of exemestane is 50 mg day-to-day following a meal.dexamethasone will decrease the extent o